Intracytoplasmic Sperm Injection (ICSI) offers patients with severe male factor infertility the opportunity to achieve a successful pregnancy when standard therapies have failed. Contact CORM (Center of Reproductive Medicine) today at 281.332.0073 to learn more about ICSI insemination and other infertility treatments in Texas.

Blastocyst Transfer and Multiple Gestation

The Center of Reproductive Medicine began exploring the potential of extended embryo culture in March of 1997 and performed the first Blastocyst transfer in October of 1997.

The success of extended culture in establishing pregnancies was dramatically enhanced with the introduction of sequential culture media.

The 2 media system is designed to provide the optimal nutritional environment for the developing embryo at select stages of growth. The implementation of extended culture into a successful ART program was a slow and careful process for our staff.

As in most ART programs (Assisted Reproductive Technologies), we are constantly reviewing our data and looking for ways to improve our techniques, while generating optimal outcomes for our patients.

In 1997 and 1998 we saw significant increases in our pregnancy rates for IVF but a trend was developing that caused us great concern. The incidence of multiple pregnancy was also increasing, especially the high order multiple pregnancy.

A high order multiple is defined as a clinical pregnancy with 3 or more gestational sacs at the time of ultrasound evaluation. We realized in the fall of 1998 that we had to examine the data and look for ways to reduce the incidence of multiple pregnancy, specifically the incidence of high order multiples.

As a result, we have developed a set of reproductive medicine guidelines that help us counsel the patients through the decision making process of Assisted Reproduction.

We have constructed our databases to group patients that are similar at the time of transfer (day 3 and day 5) and to provide outcome data to the couple prior to the transfer. Since implementing the guidelines, we have managed to maintain our pregnancy rates but have dramatically reduced the occurrence of high order multiple pregnancy.

Micromanipulation of the Human Gamete and Embryo

The Center of Reproductive Medicine has offered micromanipulation as a standard of care in the ART laboratory since 1996.

Micromanipulation involves handling the gametes (sperm and eggs) or embryos at the microscopic level by means of precision instruments attached to the microscope. The micromanipulators allow the embryologist to assist in the fertilization process (Intracytoplasmic Sperm Injection, ICSI) or promote the process of implantation of the embryo prior to transfer (Assisted Hatching, AH).

The impact of these techniques has been a major benefit to our patients by allowing us to treat couples successfully in situations where standard IVF would not. We have demonstrated success with severe male factor infertility and previous failed fertilization cases from standard ART therapies.

Contact CORM for more Intracytoplasmic sperm injection information or for information regarding other methods of infertility treatment, or if you would like to become an egg donor, by calling 281.332.0073 to speak with an infertility specialist today.